TB-500 5mg

TB-500 (Thymosin Beta-4) — Research Peptide for Tissue Regeneration and Cellular Recovery

Chemical and Biochemical Characteristics

• Amino Acid Sequence: Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser

• Molecular Formula: C₂₁₂H₃₅₀N₅₆O₇₈S

• Molecular Weight: 4963.44 g/mol

• CAS Number: 77591-33-4

• Synonyms: Thymosin Beta-4, TB-4, TB-500, Timbetasin, RGN-352, RGN-259

• Peptide Class: Naturally occurring actin-binding peptide / synthetic research analogue

• Structure Type: Linear 43-amino-acid sequence with acetylated N-terminus for increased stability

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Overview

TB-500, also known as Thymosin Beta-4 (TB-4), is a naturally occurring peptide found in nearly all human tissues.
It plays a central role in cell migration, angiogenesis, and actin cytoskeleton regulation, processes essential for tissue growth and repair.

The synthetic form, TB-500, has been widely studied for its potential regenerative and anti-inflammatory properties.
Laboratory data suggest that it may facilitate wound healing, muscle recovery, vascular regeneration, and tissue remodeling — making it a subject of significant biomedical and sports medicine research interest.

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Mechanism of Action

TB-500 acts primarily through G-actin regulation, the monomeric form of actin that underlies cytoskeletal dynamics.
By modulating actin polymerization and cell motility, TB-500 contributes to tissue regeneration and cellular communication.

Its biological effects include:

• Promotion of angiogenesis (formation of new blood vessels);

• Stimulation of keratinocyte and fibroblast migration to injury sites;

• Regulation of inflammation through cytokine modulation;

• Enhanced collagen deposition and extracellular matrix repair;

• Improved intercellular nutrient and signal exchange;

• Protection against fibrotic adhesion formation in tendons and muscles.

Through these pathways, TB-500 serves as a potent regulator of cellular organization and wound-healing dynamics.

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Tissue Regeneration and Wound Healing

Experimental models demonstrate that TB-500 accelerates the healing process in diverse tissue types — including muscle, tendon, skin, cornea, and cardiac tissue.

Key regenerative mechanisms:

• Angiogenesis: TB-500 promotes vascular endothelial cell differentiation and vessel formation, improving oxygen and nutrient delivery.

• Re-epithelialization: It stimulates the migration of epithelial cells to close wounds faster.

• Inflammation control: TB-500 helps balance the inflammatory phase of wound healing, preventing chronic inflammation.

• Fibroblast activation: Encourages fibroblast proliferation, supporting collagen synthesis and matrix rebuilding.

• Immune modulation: Enhances local immune response, reducing infection risk during tissue regeneration.

These actions highlight TB-500 as an important subject for experimental regenerative biology and tissue engineering studies.

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Muscle Repair and Performance Recovery

Preclinical research indicates that TB-500 supports muscle regeneration and strength recovery through:

• Increased angiogenesis and oxygenation in damaged tissue;

• Stimulation of satellite cell activation and muscle fiber repair;

• Reduction of inflammatory cytokines, leading to faster recovery and less soreness;

• Improved connective tissue flexibility and joint mobility.

These findings explain the compound’s research relevance in muscle physiology and recovery mechanisms after injury or intensive activity.

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Cardiac and Neurological Research

Animal studies revealed that Thymosin Beta-4 can reactivate the adult epicardium — the outer layer of the heart — enhancing cardiomyocyte migration and vascular regeneration.
This discovery positions TB-500 as a potential model compound for myocardial repair and cardiovascular tissue engineering.

Emerging data also suggest neuroprotective properties, as the peptide may influence neuronal survival and axonal growth through cytoskeletal and anti-apoptotic pathways.

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Anti-Inflammatory and Antifibrotic Activity

TB-500 has shown consistent anti-inflammatory effects in various preclinical settings, helping reduce swelling, pain, and tissue fibrosis.
By balancing immune cell signaling, it may:

• Alleviate joint inflammation;

• Prevent fibrotic scar formation;

• Support tendon and ligament elasticity;

• Promote smooth tissue remodeling after trauma.

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Safety and Research Use

TB-500 remains under active scientific investigation and is not approved for therapeutic use by the FDA or other health authorities.
Proper dosing parameters for human applications have not been established.
All available formulations are intended exclusively for laboratory and educational research purposes and must be used only by qualified professionals under controlled conditions.

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Summary

TB-500 (Thymosin Beta-4) represents a key research peptide for exploring:

• Wound healing and angiogenesis mechanisms;

• Muscle and tendon regeneration;

• Anti-inflammatory and antifibrotic signaling;

• Cardiac and neural tissue repair pathways;

• Cellular communication and actin cytoskeleton regulation.

By promoting cellular migration, angiogenesis, and tissue remodeling, TB-500 continues to be a valuable model compound in regenerative medicine and peptide-based biomedical research.

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Selected References

1. Thymosin Beta-4 Monograph. Northampton Integrative Medicine, 2019. PDF

2. Smart N., Dube K.N., Riley P.R. Thymosin Beta-4 induces adult epicardial progenitor mobilization and neovascularization. Nature, 2007; 445(7124): 177–182. PubMed: 17215842

3. Philp D., Badamchian M. Thymosin Beta-4: a key factor in tissue regeneration and inflammation control. Ann N Y Acad Sci, 2005; 1050: 157–167. PubMed: 16126940

4. Sosne G. et al. Thymosin Beta-4 promotes corneal wound healing and reduces inflammation. Invest Ophthalmol Vis Sci, 2002; 43(12): 3616–3621. PubMed: 12454048

5. Srivastava D. Thymosin Beta-4 and cardiac regeneration: activating the epicardium for repair. Circulation Research, 2013; 112(3): 600–602. PubMed: 23372022

6. Huff T. et al. Thymosin Beta-4, actin-binding proteins, and tissue plasticity. FEBS Letters, 2001; 489(2–3): 139–145. PubMed: 11165141

7. NCBI. Thymosin Beta-4 review and biochemical summary. PMC Article

 

 

Product Use: THIS PRODUCT IS STRICTLY FOR SCIENTIFIC RESEARCH PURPOSES ONLY. It should only be used in laboratory settings. All product information on this website is provided solely for educational purposes. The law strictly prohibits introducing this product into the body of humans or animals. Only licensed professionals should handle this product. This product is not a drug, food, or cosmetic and should not be improperly classified or used as such.