AOD-9604 5mg

AOD-9604 (GH Fragment 176-191)

Chemical Identity

• Type: Synthetic peptide fragment of human growth hormone (hGH)

• Sequence: Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe

• Disulfide Bridge: Cys7–Cys15

• Molecular Formula: C₇₈H₁₂₃N₂₃O₂₃S₂

• Molecular Weight: 1815.12 g/mol

• CAS Number: 386264-39-7

• PubChem CID: 16131447

• Synonyms: AOD-9604, GH Frag 176-191

Overview

AOD-9604 is a modified analog of the human growth hormone fragment 176-191, designed to selectively replicate the lipolytic (fat-burning) properties of hGH while eliminating its undesirable effects on insulin, IGF-1, or glucose metabolism.

Unlike full-length hGH, AOD-9604 does not promote muscle hypertrophy, water retention, or hyperglycemia.
Its biological activity is focused almost entirely on enhancing fat metabolism, supporting cartilage repair, and improving metabolic flexibility — without altering growth hormone pathways.

Mechanism of Action

AOD-9604 acts by mimicking the C-terminal domain of the hGH molecule responsible for stimulating the breakdown of triglycerides and inhibiting their re-accumulation in adipose tissue.

It primarily enhances:

• Lipolysis: increases fat oxidation and the release of fatty acids from adipocytes.

• Anti-lipogenesis: inhibits the formation of new fat cells and lipid storage.

• Mitochondrial metabolism: improves β-oxidation efficiency and cellular energy turnover.

Research shows AOD-9604 achieves these effects without activating the IGF-1 axis, distinguishing it from anabolic growth-hormone therapies.

Research Highlights

🔥 Fat-Metabolism & Weight-Management Studies

Originally developed as an anti-obesity compound, AOD-9604 underwent phase II trials showing a significant increase in fat loss compared to placebo.
Participants experienced sustained weight reduction over 12 weeks without developing resistance to the peptide’s action — suggesting durable metabolic modulation rather than temporary appetite suppression.

Animal research further indicates that AOD-9604’s activity is not limited to β₃-adrenergic receptor pathways, meaning its fat-burning action may involve alternative metabolic cascades such as AMPK activation and apoptosis of mature adipocytes.

🦴 Joint Health & Cartilage Regeneration

Beyond its lipolytic action, AOD-9604 demonstrates tissue-repair and anti-inflammatory properties in preclinical joint-injury models.
Intra-articular studies in arthritic animals revealed improvements in cartilage structure, reduced inflammation, and lower pain sensitivity — suggesting that the peptide may promote chondrocyte regeneration and protect joint integrity.
The effect appears synergistic when combined with hyaluronic acid or other regenerative agents.

❤️ Metabolic and Cardiovascular Support

While fat-loss alone reduces cardiovascular risk, AOD-9604 may exert direct metabolic benefits independent of body-weight reduction.
Research points to improved lipid oxidation, glucose regulation, and insulin sensitivity, potentially reducing complications associated with metabolic syndrome.
This secondary mechanism implies that AOD-9604 influences systemic metabolism at a cellular level — aligning with the broader class of metabolic modulators rather than simple weight-loss agents.

Key Properties

• Targets adipose tissue metabolism without elevating IGF-1.

• Promotes fat oxidation and reduces fat accumulation.

• Supports cartilage recovery and joint mobility.

• Demonstrates a strong safety profile and non-immunogenic structure.

• Studied as an adjunct for metabolic, orthopedic, and cardiovascular applications.

Summary

AOD-9604 represents the next generation of growth-hormone-derived research peptides — designed for fat metabolism, tissue repair, and metabolic homeostasis rather than anabolic growth.
Its unique selectivity makes it a versatile tool in experimental studies focusing on:

• obesity and lipid regulation,

• joint and cartilage regeneration,

• metabolic and cardiovascular health, and

• mitochondrial energy optimization.

In short, AOD-9604 bridges the gap between lipolytic signaling and regenerative peptide science, offering a refined model for studying body composition and metabolic resilience.

Product Use: THIS PRODUCT IS STRICTLY FOR
SCIENTIFIC RESEARCH PURPOSES ONLY. It should only be used in laboratory
settings. All product information on this website is provided solely for
educational purposes. The law strictly prohibits introducing this product into
the body of humans or animals. Only licensed professionals should handle this
product. This product is not a drug, food, or cosmetic and should not be
improperly classified or used as such.