BPC-157 10mg

BPC-157 is a peptide initially isolated from human gastric juice, comprising 15 amino acids. It’s considered a stable fragment of a larger peptide known as “Body Protection Compound.” BPC-157 has garnered significant attention in scientific studies for its potential anti-inflammatory and regenerative properties. Preliminary research suggests it may aid in healing various injuries, including joint, muscle, nerve damage, and even gastrointestinal ulcers. Additionally, it shows potential in treating inflammatory bowel diseases.

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Amino Acid Sequence: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val

Molecular Formula: C62H98N16O22

Molecular Weight: 1419.556 g/mol

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BPC-157, also known as Body Protection Compound-157, is derived from a naturally occurring protein in the human digestive tract. Its primary function is to protect the gastrointestinal tract’s mucosal lining, promote healing, and stimulate blood vessel growth.

The synthetic version, BPC-157, is a pentadecapeptide consisting of 15 amino acids extracted from the larger BPC protein. Remarkably, it retains many of the therapeutic properties of its parent molecule. BPC-157 is particularly beneficial in the following areas:

 • Wound healing

 • Promoting blood vessel growth

 • Influencing the blood coagulation cascade

 • Generating nitric oxide

 • Enhancing immune system function

 • Modulating gene expression

 • Regulating hormones, especially in the gastrointestinal nervous system.

BPC-157: A Promising Aid for Healing Connective Tissue Injuries

Given its role in attracting fibroblasts and promoting vascular growth, it’s no surprise that BPC-157 has shown promising results in animal models for injuries to tendons, ligaments, bones, and other connective tissues. Tendon and ligament injuries heal slowly, primarily due to limited blood supply to these tissues. Insufficient blood flow hinders the timely arrival of fibroblasts and other cells that promote healing, leading to restricted overall recovery. Both in vitro and in vivo studies involving rat tendons have demonstrated that BPC-157 enhances collateralization and increases fibroblast density in the context of injuries to tendons, ligaments, and bones. These findings suggest that BPC-157 is more effective in facilitating the healing of these tissues compared to hormones such as bFGF, EGF, and VGF.

Moreover, experiments using FITC-phalloidin staining have shown that BPC-157 acts as a potent stimulator of F-actin formation in fibroblasts. F-actin is crucial for cellular structure and function, particularly for cell migration. Western blot analysis further indicated that BPC-157 enhances the phosphorylation of proteins paxillin and FAK, which are key components of the cell migration pathway.

BPC-157 and Wound Healing: Enhancing Fibroblast Activity

The natural role of BPC in the gastrointestinal tract is to protect the integrity of the mucosal lining, shielding the underlying tissues from the harmful effects of stomach acid, bile, and other digestive compounds necessary for nutrient absorption from food. A crucial part of this function involves attracting fibroblasts. BPC-157 has a dose-dependent effect on the behavior of fibroblasts both in culture and in vivo, leading to enhanced proliferation and migration of these cells. Fibroblasts play a vital role in the healing process as they are responsible for the deposition of important extracellular matrix proteins, such as collagen, fibrin, elastin, and others. These proteins are essential for repairing and strengthening the injured tissue, making BPC-157 a significant player in promoting efficient wound healing.

BPC-157 and Medication Side Effects: A Promising Solution

A primary issue in the medical use of pharmaceutical drugs is the side effects they induce. For example, NSAIDs like ibuprofen should not be used long-term due to their potential to cause gastric bleeding and increase the risk of heart attacks. Modern medical research aims to mitigate these side effects while preserving the desired therapeutic effects, as this could significantly enhance the benefits of various medications. Notably, BPC-157 has demonstrated its ability to counteract side effects associated with NSAIDs, some psychiatric medications, and several cardiac drugs.

It’s not surprising that BPC-157 is effective in preventing many gastrointestinal (GI) tract side effects associated with certain medications. However, less obvious is that this peptide also offers protection against side effects in the brain, heart, and other tissues. In rat studies, BPC-157 has shown its ability to protect against QTc prolongation in the heart, a condition that can lead to serious and potentially fatal arrhythmias. QTc prolongation is often induced by drugs used to treat diabetes, schizophrenia, and other psychiatric conditions.

Furthermore, BPC-157 has demonstrated its ability to prevent other side effects of psychiatric drugs, including severe issues such as catalepsy and somatosensory disorders. This last benefit could potentially greatly improve the treatment of psychiatric conditions known for their complexity in management, partly because patients often discontinue their medication due to severe side effects.

BPC-157: Enhancing Vascular Growth and Collateralization

BPC-157 is a potent angiogenic factor renowned for significantly accelerating the proliferation and growth of endothelial cells that line blood vessels. Rat studies have demonstrated that this peptide markedly speeds up the growth of collateral blood vessels in ischemic conditions. Although this effect was primarily observed in the gastrointestinal tract, increasing evidence suggests similar benefits in cardiovascular, neurological, and muscular tissues. This indicates that BPC-157 may have potential in therapies for stroke and myocardial infarction, as well as serving as a research peptide for exploring mechanisms that facilitate healing after ischemic injuries.

Additionally, research on chicken embryos shows that BPC-157’s stimulation of vascular growth is partly achieved through the stimulation of VEGFR2, a cell surface receptor playing an active role in the nitric oxide signaling pathway. VEGFR2 is crucial for the growth, proliferation, and longevity of endothelial cells.

Cell culture studies have successfully demonstrated that introducing BPC-157 leads to “vascular chasing.” This term refers to the growth of blood vessels towards a damaged or blocked area to restore blood flow to surrounding tissues, preserving cellular function. This unique ability of BPC-157 opens up potential for developing effective oral treatments for slowly progressing arterial occlusions typically seen in conditions like atherosclerotic heart disease. Future research in this area could potentially reduce the need for invasive surgical interventions, such as stenting and coronary artery bypass grafting.

Expanding the Therapeutic Potential of BPC-157: New Research Frontiers

BPC-157 has demonstrated extensive potential in medical research, exploring its properties and applications across several areas that complement its known effects:

 Neuroprotective Actions: BPC-157 may offer protective benefits for nerve cells, presenting opportunities for treating neurodegenerative diseases such as Parkinson’s and Alzheimer’s.

 Immune System Modulation: The peptide can regulate immune system activity, helping to reduce autoimmune reactions and allergic responses.

 Treatment of Psychiatric Disorders: Studies have shown that BPC-157 can alleviate symptoms of disorders like depression and anxiety through the stabilization of neurotransmitter systems.

 Peripheral Nerve Regeneration: The peptide is being researched for its ability to promote the regeneration of damaged peripheral nerves, potentially revolutionizing the treatment of injuries and surgical interventions.

  Anti-Cancer Research: Preliminary data suggest that BPC-157 may inhibit the growth of tumor cells, opening doors for future oncological research.

  Liver Disease Treatment: BPC-157 may improve liver function and protect it from damage caused by toxins and alcohol, offering a promising tool for combating conditions such as hepatitis and cirrhosis.

  Skin Health Effects: Beyond enhancing collagen synthesis, BPC-157 can promote skin health by reducing inflammatory processes and accelerating wound healing.

  Sports Medicine Potential: The use of BPC-157 in sports medicine for speeding up recovery after injuries and improving muscle regeneration could provide an alternative to traditional treatment methods and enhance training efficacy.

These additional research directions for BPC-157 deepen our understanding of its promising properties and expand the application areas, opening new possibilities for therapy and rehabilitation across various medical fields.

Product Use: THIS PRODUCT IS STRICTLY FOR SCIENTIFIC RESEARCH PURPOSES ONLY. It should only be used in laboratory settings. All product information on this website is provided solely for educational purposes. The law strictly prohibits introducing this product into the body of humans or animals. Only licensed professionals should handle this product. This product is not a drug, food, or cosmetic and should not be improperly classified or used as such.