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P21 is a cutting-edge nootropic peptide designed to enhance cognitive function and support neurogenesis. It targets several key mechanisms involved in brain health and recovery, making it particularly relevant for conditions such as Alzheimer's disease and stroke recovery.


Enhanced Cognitive Functioning: P21 supports improved cognitive performance and neurogenesis.

Stroke Recovery: It aids in the recovery of brain function following a stroke.

Neural Regeneration in Alzheimer’s: P21 helps in regenerating neural pathways and combating Alzheimer's-related damage.

Mechanism of Action: P21 works by increasing levels of Brain-Derived Neurotrophic Factor (BDNF), which plays a crucial role in nerve growth and cognitive function. BDNF not only promotes neurogenesis but also inhibits the formation of amyloid plaques and tau proteins, which are characteristic of Alzheimer's disease.

Research Highlights:

Increased BDNF Levels: Boosts BDNF levels, contributing to enhanced neurogenesis and cognitive improvement.

Inhibition of Amyloid Plaques and Tau Proteins: Helps to reduce the formation of amyloid plaques and tau proteins, which are associated with Alzheimer's disease.

Enhanced Mitosis: Demonstrated a 150% increase in mitotic cells in the dentate gyrus, indicating enhanced neurogenesis.

Improved Neural Markers: Higher levels of AMPA receptor proteins (Glur2 and Glur3), Phosphorylated GSK3B, and DCX, which are indicative of improved neural activity and plasticity.

Sex-Dependent Variations: Studies primarily use female subjects due to the more aggressive nature of tau diseases in females. This focus helps to provide more accurate insights into the peptide's effects in conditions related to tau protein accumulation.


Typical Use: P21 is often administered over long-term periods to achieve optimal cognitive and neurogenic effects.

Conclusion: P21 represents a promising approach for those looking to enhance cognitive function, support brain recovery post-stroke, and combat neurodegenerative diseases like Alzheimer’s. Its ability to boost BDNF levels and inhibit detrimental brain proteins makes it a valuable tool in neurogenesis and cognitive health.


Molecular formula:  C30H54N6O5

Molecular weight:   578.8 g/mol



Research Applications:     

Neurogenesis

Appetite Regulation


Product Use: THIS PRODUCT IS STRICTLY FOR SCIENTIFIC RESEARCH PURPOSES ONLY. It should only be used in laboratory settings. All product information on this website is provided solely for educational purposes. The law strictly prohibits introducing this product into the body of humans or animals. Only licensed professionals should handle this product. This product is not a drug, food, or cosmetic and should not be improperly classified or used as such.

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